ERC Starting Grant · 2019
Genetically enhanced, optically superior tissues (GHOSTS)
Most biological tissues are optically opaque, largely precluding access by light microscopy. In stark contrast, some living tissues and organisms are highly transparent. Examples include many deep-sea fish, your retina, and cells that we exposed to directed evolution. Here we propose to uncover the genetic basis of tissue transparency, such that living cells and tissue cultures can be optically cleared by precision genetics. For this we will combine insights into origins of retina transparency, and a unique of methods, to answer the question how genetically cells become more transparent during directed evolution. Specifically, we will use a three-fold approach to find transparency genes…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.