ERC Advanced Grant · 2020
Transcriptional Adaptation and Genetic Compensation
Organisms utilize several mechanisms to compensate for the damaging consequences of genetic perturbations. One such mechanism is the newly identified process of transcriptional adaptation (TA): in this process, certain deleterious mutations trigger the transcriptional modulation of so-called adapting genes. In some cases, e.g., when one of the upregulated genes is functionally redundant with the mutated gene, TA leads to functional compensation. Notably, unlike other modes of compensation, TA is not triggered by the loss of protein function. This unexpected observation has prompted studies into the machinery of TA and the contexts in which it functions. Following our discovery of TA (Rossi…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.