ERC Advanced Grant · 2020
Mechanisms of gradient decoding in fission yeast
How does a cell orient in response to a chemical cue? This basic problem is at the core of how cells interact with their environment. Indeed, the ability to move towards the source of a chemical gradient underlies behaviours as diverse as feeding, identifying a foreign invader or building interconnected cellular networks. Furthermore, chemo-orientation forms the basis of gamete recognition, and is thus critical for genome diversification through sexual reproduction. This proposal makes use of one of the simplest eukaryotic models, the fission yeast S. pombe, to systematically dissect the mechanisms of gradient detection. Gradient sensing occurs during sexual reproduction in a speed-dating…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.