ERC Consolidator Grant · 2020
Understanding gene regulation in nuclear space
There is accumulating evidence for a new gene expression paradigm, in which genes and transcription factors cooperate to create specialized nuclear hotspots optimized for transcription. How hotspots form, and how they impact transcription, however, is unclear. This is mostly because mechanistic and functional approaches have been limited by the large number of hotspots per nucleus, their small size, and their transient nature. Here, wThere is accumulating evidence for a new gene expression paradigm, in which genes and transcription factors cooperate to create specialized nuclear hotspots optimized for transcription. How hotspots form, and how they impact transcription, however, is unclear.…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.