ERC Starting Grant · 2020
Zygotic Cell Fate and Parent-Biased Gene Expression in Fission Yeast
As two gametes fuse, the newly formed zygote immediately represses mating, to prevent polyploid formation, and triggers the developmental program that gives rise to a new individual. My work showed that zygotes of fission yeast and higher eukaryotes bare striking similarities, and here I propose to use this powerful model system to explore the basic mechanisms of gamete-to-zygote transition. Working in fission yeast, where gametes and zygotes are well-defined and accessible to outstanding plethora of experimental approaches, will show how different regulatory mechanisms synergize to execute this key cell fate switch. Our first aim explores zygotic regulation of gene expression and mating…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.