Bothma Lab

Research focus

ERC Starting Grant · 2020

Illuminating the role of transcription factor dynamics in development

Understanding how genomic regulatory elements encode when and where genes are expressed in development remains one of the most important open questions in biology. Despite intense study, this knowledge gap persists because technological limitations have obscured an important degree of freedom: time. Recent discoveries made with live cell imaging have defied the textbook view of how transcription is regulated. Hence, the time is ripe to introduce a new paradigm for studying transcription in development—one based on how genes are regulated in living animals as development is actually taking place. Excitingly, we can now exploit the cutting-edge live imaging technology and quantitative…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.