ERC Starting Grant · 2020
Uncovering the machinery for the sorting of newly synthesized proteins into the axon
Neuronal development and function rely on the polarized distribution of organelles and transmembrane proteins (cargoes) across their somatodendritic and axonal domains. However, it is unknown how organelle organization regulates the polarized sorting of transmembrane proteins to ensure proper neuronal function. The classical model for sorting of newly synthesized transmembrane proteins to the plasma membrane (PM) follows the biosynthetic pathway via the rough endoplasmic reticulum (ER) and Golgi, which are restricted to the somatodendritic domain in neurons. It is unclear whether this classical secretion pathway is the main route for cargo sorting into the axon or whether an alternative…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.