ERC Advanced Grant · 2021
Coordination of mouse embryogenesis in space and time at implantation
Self-organisation is a defining feature of living systems and entails complex interplay between multiple parameters across various spatio-temporal scales. Using pre-implantation mouse embryos as a model system, our studies revealed a principle of regulative development, in which feedback between cell fate, polarity and mechanics ensures robust control of embryo size, shape and pattern. However, as embryos undergo implantation, this self-organisation mechanism has to be integrated in its spatio-temporal context. In this project, we aim to understand how developmental mechanisms are coordinated in space and time. The peri-implantation mouse embryo is an attractive system in which to study…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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