ERC Consolidator Grant · 2021
Niche geometry as the regulator of communal metabolism and cell fate
Tissue renewal by adult stem cells is regulated by a multitude of cell intrinsic and extrinsic mechanism, which jointly guide decisions between stem cell self-renewal and differentiation. Change between these two cellular fates is considered to result from transcriptional events that sequentially alter the function of the whole cell – including its metabolism. However, recent findings by us and others demonstrate that metabolism can actually actively influence cell fate. Moreover, metabolites can be exchanged between neighbor cells in the stem cell niche, raising the question on how cell fate can be accurately controlled. I hypothesize that fate of tissue stem cells is controlled by…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.