Delarue Lab

Research focus

ERC Starting Grant · 2021

Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressure

Growth-induced pressure necessarily emerges when a cell population, whichever the organism, proliferates in a 3D spatially-limited environment. Growth-induced pressure imposes physical constraints on cell physiology. A reduction of growth and division is observed in evolutionarily distant organisms such as bacteria, fungi, plants, or mammals. However, some cells are more capable of coping with these physical limitations and proliferate than others. This is in particular the case of cancer cells, for which growth-induced pressure participates in tumorigenesis and chemoresistance. Despite its importance, we are still at a loss to identify the basic sensing mechanisms associated with 3D…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.