ERC Starting Grant · 2021
Cytokine and microbiota function in gut development: spatiotemporal analysis in the zebrafish
Organ development and function are controlled by complex interactions between genetic, cellular, and environmental factors. Because these interactions are challenging to study in live organisms, their mechanisms remain largely unknown. Gut development is regulated by microbiota colonization, making it a valuable organ for dissecting gene-environment interactions. Cytokines, small secreted proteins highly responsive to environmental changes, regulate immunity and gut function in mammals. Our data indicate that specific cytokines are also essential for gut development in zebrafish. We found that these cytokines are first expressed in gut epithelial cells during development, and later their…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at National Institute of Health and Medical Research (INSERM)