ERC Starting Grant · 2021
The fundamentals of cardiovascular calcification: from cells to therapy
With this project I propose to identify fundamental mechanisms of cardiovascular calcification (CVC) and new therapeutic targets using zebrafish as a model system. CVC, characterised by progressive calcification of the soft tissue causing impaired blood circulation, is a frequent form of cardiovascular disease. Because the pathophysiology of CVC is highly heterogeneous, the exact cell types and signalling pathways triggering tissue calcification are still unknown, thus limiting therapy options. Most studies on CVC rely on in vitro systems, which fail to reproduce the multicellular environment, or mammalian in vivo models, limited for live-imaging and high-throughput analyses. By combining…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at National Institute of Health and Medical Research (INSERM)