ERC Consolidator Grant · 2022
A hallmark of meiosis is chromosomal pairing, which for decades has been a major focus in the field. However, the nuclear events of meiosis occur in the cellular context of a differentiating gamete, and pairing depends on cytoplasmic counterparts, by mechanisms that are conserved from yeast to mammals. These are essential for fertility, but how cytoplasmic counterparts of chromosomal pairing are regulated has remained enigmatic. We uncovered a previously unrecognized cilium in meiosis – the zygotene cilium, in both males and females and in zebrafish and the mouse, which completes the mechanical cytoplasmic pairing machinery, and extracellularly extend between oocytes within a conserved…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.