ERC Consolidator Grant · 2022
Mechanisms of liver regeneration and disease across scales; from molecules to cells and tissue
Despite recent advances, the principles that regulate liver regeneration and how their deregulation leads to disease remain largely unknown. The main goal of this application is to uncover molecular and cellular principles that govern liver regeneration and disease and exploit this knowledge to develop more complex multicellular organoid systems capable of reconstructing liver tissue in a dish. We will adopt a multi-scale (from molecule to tissue), and multidisciplinary approach, addressing the interplay between cell-intrinsic and cell-extrinsic mechanisms in damage paradigms that result in repair vs disease. In Aim 1 we will identify the genomic loci (e.g. Transcription factors, signalling…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.