ERC Consolidator Grant · 2022
Physics of the first mammalian epithelium
Epithelia operate major biological functions throughout the human body. Forming de novo during preimplantation development, the trophectoderm (TE) is our first epithelium. The TE mediates the formation of the first mammalian lumen, which involves considerable physical challenges. Indeed, pressurized fluid, pumped through the TE, fractures intercellular contacts before cells squeeze this fluid into a single lumen. We recently found that cell adhesion and cell contractility determine the position of this lumen, which then controls further differentiation of the TE. This suggests that physical cues can determine the first mammalian axis of symmetry and TE patterning. However, most physical…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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