ERC Consolidator Grant · 2022
Deciphering Cellular Networks for Membrane Protein Quality Control Decisions
Any cell and each of its organelles needs to interact with its environment. Membrane proteins, which span the plasma membrane and the multiple endomembranes of a eukaryotic cell, mediate these interactions. They allow cells to move, thrive and defend - and multicellular organisms to exist. Humans dedicate almost one third of their genes to membrane proteins. Failures in membrane protein biogenesis or function cause numerous human diseases from cancer to neurological disorders. By far most eukaryotic membrane proteins are produced at one organelle, the endoplasmic reticulum (ER), where a dedicated protein folding and quality control machinery supports and controls protein structure…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.