Gur Lab

Weizmann Institute

- · Israel

ERC-funded
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ERC Starting Grant · 2022

Unraveling the molecular mechanisms underlying intracellular crystal formation

From vision in teleost fish to the spectacular colors reflected from reptiles and crustaceans, intracellular molecular crystals play vital roles in the function of cells and the ecology of organisms. These crystals are formed in specialized cellular vesicles termed iridosomes, where their properties are controlled in ways that cannot be matched by modern technology. Failure to control crystal formation can be deleterious to organisms, obstructing fundamental abilities, such as vision, body temperature regulation, camouflage, and kin recognition, and underlying pathologies such as gout and kidney stones in humans. Exploring the fascinating ability of iridosomes to perform such elaborate…

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