ERC Consolidator Grant · 2023
Understanding of the Membrane Connection Linking the Nucleus to the Endoplasmic Reticulum
Compartmentalization into membrane-bound organelles is a key feature of all eukaryotic cells, and communication between organelles needs to be tightly controlled. A key organelle for the inter-organelle communication is the endoplasmic reticulum (ER), which is the major site of lipid and membrane protein synthesis. The ER exchanges molecules by forming stable contact sites with multiple organelles such as mitochondria via specific tethering proteins and transporters. In contrast to these contact sites, the ER is linked to the nucleus via direct fusion to the outer nuclear membrane of the nuclear envelope (NE). These ER-NE junctions are essential for supplying the lipids and proteins that…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.