ERC Starting Grant · 2023
Cell size as driver of stem cell aging and cancer
The failure to regenerate tissue underlies a challenging health issue in elderly. A main contributor to this decline is the loss of stem cell function during aging. Despite the essential role of stem cells, it is unclear how they fail to maintain their functions during aging and disease. I discovered a new aspect of stem cell aging in vivo: cellular enlargement. With age, stem cells increase in size leading to their functional decline. However, it is unclear how size impacts stem cell fitness. Moreover, the physiological importance of this process remains unsolved. My team at the University of Helsinki will address these questions by: (1) identifying pathways that promote stem cell…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.