Zapata Lab

Saarland University

Saarland (DEC) · Germany

ERC-funded
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ERC Starting Grant · 2023

Opposites attract: Crosstalk between vimentin and microtubules - mechanical stability vs. dynamic adaptability

The cytoskeleton is mainly composed of actin, microtubules, and intermediate filaments. It is fundamentally important for many cellular processes, which is reflected in its morphological and functional diversity. In the past, in-depth analysis of actin and microtubule networks made it possible to reconstitute their diversity in vitro with astonishing precision. This enabled a detailed understanding of the mechanisms underlying actin and microtubule network formation, which are the basis for many cellular processes. In contrast, our knowledge of intermediate filaments is still in its infancy, and we are far from rebuilding complex intermediate filament networks and their interactions with…

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