Lecuit Lab

Research focus

ERC Advanced Grant · 2024

Geometric constraints and feedback during tissue morphogenesis

During development, cell movements and shape changes give rise to complex 3D forms. What underlies the fidelity of morphogenesis? To date, much emphasis has been placed on understanding how genes and local mechanics drive cell shape changes and tissue scale morphogenesis. However, the roles of the geometric properties of a tissue and its physical boundaries, their size, dimensionality, curvature and overall shape have recently emerged as important yet overlooked features of morphogenesis. This interdisciplinary project will unravel how geometry and geometric feedbacks constrain lower scale cell mechanics and how they contribute to tissue morphogenesis. We will study the interplay between…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.