ERC Starting Grant · 2024
Tight junctions and tissue mechanics as sensors and executers of heart regeneration
One of the most fascinating aspects of salamander regeneration is the level of precision at which restoration of complex structures occurs. How the recovery of form and function is sensed at a cellular level leading to appropriate termination of regenerative programs remains largely unknown. This is partly due to technical challenges of studying cellular events at a high-resolution during regeneration and establishing a constitutive link between cell behavior, tissue architecture and function. Here, I propose taking an interdisciplinary approach that combines gene editing, deep-tissue imaging, force measurements and spatial -omics to overcome these barriers. My goal is to gain holistic…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.