Deshwal Lab

Research focus

ERC Starting Grant · 2024

Mitochondrial Strategies in Ferroptotic Cell Death

Mitochondria serve as the epicenter of cellular metabolism. Their dynamic communication with other compartments within the cell ensures proper cellular function. My recent work reveals how mitochondria communicate with the plasma membrane (PM) to transport a redox-active lipid Coenzyme Q (Ubiquinone or CoQ). This communication is crucial for inhibiting a form of iron-mediated cell death called ferroptosis. Notably, CoQ is exclusively synthesized within the mitochondria and plays a pivotal role in maintaining the mitochondrial respiratory chain, as well as other metabolic pathways, such as pyrimidine synthesis, fatty acid oxidation and proline metabolism. My work highlights that cellular…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.