ERC Starting Grant · 2024
3-dimensional Organization and Functions of Translation in Organelle Proximity
In eukaryotic cells, many proteins are produced next to the organelles where they function, demonstrating a link between translation and protein targeting. The mechanisms of this connection are mostly unknown. In this proposal, I bring together the fields of translation regulation and organelle biogenesis to find this out. I approach the problem with a powerful combination of functional genomics and cryogenic electron tomography (cryo-ET). First, I want to create a quantitative map of proximal translation next to all the organelles and their sub-domains. Using high-throughput imaging, I will determine localizations of all the mRNAs and their dependence on translation. I will also map the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.