ERC Consolidator Grant · 2025
Robustness of morphogenesis via noise and mechano-chemical feedbacks
Development involves increasingly intricate processes of physical tissue sculpting (morphogenesis), resulting in highly reproducible shapes. The apparent paradox between reproducibility at macroscopic scales, and emerging evidence of extensive heterogeneity and stochasticity at the molecular and cellular scales, suggests that active mechanisms are necessary to ensure morphogenetic robustness. However, as biomechanical theories of morphogenesis have largely ignored the presence and many facets of noise, robustness remains poorly defined. We hypothesize that mechano-chemical feedbacks between signaling, forces and geometry provide correction mechanisms that not only mitigate noise, but can…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.