ERC Consolidator Grant · 2025
Somitogenesis – Information transmission by noisy oscillators
How do cells communicate robustly despite noise to enable development and homeostasis in multicellular systems? Encoding biological information in signalling pathway dynamics can enhance robustness and signal versatility. Oscillatory activity is a key type of signalling dynamics. Somitogenesis, the periodic segmentation of vertebrate embryos, serves as a model system for studying signalling oscillations in embryonic development. It leads to the formation of somites, transient structures that give rise to vertebrae, axial muscles and other tissues. In anterior unsegmented tissue, single cells commit to differentiation and somite formation. However, our single-cell tracking reveals that…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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