ERC Starting Grant · 2025
The role of cell type-specific timing in the robustness of development
Reproducibility in development is maintained via precisely-timed execution of gene regulatory programs required to build all cell types of the embryo. However, many perturbations challenge this robustness and accelerate developmental tempo, leading to increased phenotypic variability. Mechanisms underlying this century-old observation have been obscured by variation inherent to embryogenesis, but advances in statistical single-cell profiling have revealed an unappreciated source of variability: non-uniform progression of development across cell types. Here, I propose to use a combination of ultra-scalable single-cell genomics, cross-species alignment of developmental trajectories, and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.