ERC Starting Grant · 2025
Lysosomes are the central degradative organelle of all cells and function as logistic centres of cellular metabolite flux. Their dysregulation underlies ~70 monogenetic lysosomal storage disorders, metabolic syndromes, neurodegenerative maladies, and aging, thus affecting an ever-growing portion of the human population. A frequent denominator in these pathophysiological conditions is the deposition of lipids and lipid metabolites in the lysosomal lumen which leads to the accumulation of dysfunctional lysosomes, inflammatory responses, and cell death. The molecular mechanisms governing lipid flux through lysosomes are poorly understood, despite their importance for human disease. My proposed…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.