Baghdadi Lab

Research focus

ERC Starting Grant · 2025

Mechanical regulation of the intestinal stem cell niche in development and disease

Tissue turnover and regeneration are orchestrated by stem cells that both differentiate and self-renew. The balance between self-renewal, proliferation, and commitment depends on the stem cell microenvironment, or “niche”. Importantly, stem cells are not simply passive responders to their niches; instead, they play an integral role in building and communicating with their immediate microenvironment. Although multiple studies have described the molecular and cellular composition of the niche to date, it is still unclear if and how the mechanical properties of the microenvironment regulate stem cell emergence and maintenance. This research project investigates the intricate dynamics between…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.