ULB - Free University of Brussels
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest (BE1) · Belgium
ERC Starting Grant · 2025
Deciphering the COMPASS that guides cancer
Epigenetic features are commonly dysregulated in cancer and one of the surprising findings from the sequencing of cancer genomes is the high rate of alterations in many epigenetic regulators. KMT2D/MLL4, KMT2C/MLL3 and KDM6A/UTX are among the most frequently mutated genes in a wide range of cancers and in normal aged epithelial cells. Interestingly, these three genes are components of the same complex, COMPASS-like complex that regulate enhancer activity and regulate gene expression in a lineage specific manner. The deletion of members of the COMPASS-like complex has been associated with altered differentiation, aging and tumorigenesis. However, the precise mechanisms by which mutations in…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.