ERC Starting Grant · 2025
Single-cell OMICS-informed in vitro models of human development
From immunotherapy to restoring neural function in Parkinson’s disease, cell-based therapies are shaping medicine. Human pluripotent stem cells (hPSCs) could be an invaluable resource, given their unlimited in vitro self-renewal and ability to differentiate into any cell-type. However, in vitro hPSC-derived cells show defective performance in transplantation assays. Using the long-sought in vitro production of hematopoietic stem cells (HSCs) as a model, I propose a strategy to assess and rectify the accuracy of hPSC differentiation protocols in recapitulating embryonic cell fate decision processes: AIM1 Establish an analysis workflow to systematically compare hPSC-derived developmental…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.