ERC Consolidator Grant · 2016
Quantitative analysis of DNA methylation maintenance within chromatin
Cytosine methylation is a chemical modification that is precisely copied when DNA is replicated. Because methylation can regulate gene expression, accurate reproduction of DNA methylation patterns is essential for plant and animal development and for human health. The enzymes that maintain DNA methylation have to work within chromatin, and particularly to contend with nucleosomes – tight complexes of DNA and histone proteins. How methylation of nucleosomal DNA is maintained remains unknown, and even the simple matter of whether nucleosomes hinder or promote methylation is controversial. My laboratory’s recent work with DDM1 – an ancient protein conserved between plants and animals that can…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.