Treutlein Lab

Research focus

ERC Starting Grant · 2017

Reconstructing human cortex development and malformation with single-cell transcriptomics

Technologies to sequence single-cell transcriptomes (scRNA-seq) are revolutionizing our ability to analyze cell composition and differentiation in complex tissues. In parallel, recent innovations allow the generation of three-dimensional tissues from stem cells that recapitulate human development. In this proposal, we will focus on human cortex development modelled by cerebral organoids. Our vision is to create an integrative single-cell transcriptomic platform to reconstruct cerebral organoid development, and dissect network alterations that lead to human brain malformations. Our project will be advanced through the following objectives: 1. Single-cell transcriptome-coupled lineage…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.