Ghavi-Helm Lab

Research focus

ERC Starting Grant · 2017

Regulatory genomics during Drosophila embryogenesis: dissecting enhancer-promoter interactions

In eukaryotes, the complex regulation of temporal- and tissue-specific gene expression is controlled by the binding of transcription factors to enhancers, which in turn interact with the promoter of their target gene(s) via the formation of a chromatin loop. Despite their importance, the properties governing enhancer function and enhancer-promoter loops in the context of the three-dimensional organisation of the genome are still poorly understood. My recent work suggests that (i) developmental genes are often regulated by multiple enhancers, sometimes located at great linear distances, (ii) the spatio-temporal activity of a large fraction of those enhancers remains unknown, (iii)…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.