Cacchiarelli Lab

Telethon Foundation

Centro (IT) (ITI) · Italy

ERC-funded
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ERC Starting Grant · 2017

Dissecting the regulatory logic of cell fate reprogramming through integrative and single cell genomics

The concept that any cell type, upon delivery of the right “cocktail” of transcription factors, can acquire an identity that otherwise it would never achieve, revolutionized the way we approach the study of developmental biology. In light of this, the discovery of induced pluripotent stem cells (IPSCs) and cell fate conversion approaches stimulated new research directions into human regenerative biology. However, the chance to successfully develop patient-tailored therapies is still very limited because reprogramming technologies are applied without a comprehensive understanding of the molecular processes involved. Here, I propose a multifaceted approach that combines a wide range of…

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