ERC Advanced Grant · 2019
Determining in vivo protein structures and understanding genetic interactions using deep mutagenesis
The goal of my research is to understand mutations and how they interact to alter phenotypes and disease. We recently initiated a new research direction that uses systematic (‘deep’) mutagenesis to quantify, understand, and predict how diverse mutations interact non-additively within and between molecules to affect phenotypes at multiple scales. Very excitingly, we have also shown that quantifying genetic interactions by deep mutagenesis provides sufficient information to determine the 3D structures of proteins. In this project we will leverage this experience in deep mutagenesis and computational modelling to address three specific aims: 1. To develop simple generic experimental and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.