ERC Advanced Grant · 2019
Overcoming chromatin restricted DNA access
Differential gene expression programs account for the diversity of cell types in our body. They are controlled by intricate networks of sequence-specific transcription factors (TFs) that operate in the context of chromatin. Chromatin is itself an essential component of this process, and is part of the system that selectively restricts DNA access for TFs. As a consequence, most TFs only bind to a small subset of their motif occurrences, in a way we currently do not fully understand. Our inability to predict binding of a TF based on its cognate motif and location in the genome is a serious obstacle towards predictive models of gene regulation. DNAccess has the ambitious goal to define in vivo…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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