Picotti Lab

Research focus

ERC Consolidator Grant · 2019

Three-dimensional dynamic views of proteomes as a novel readout for physiological and pathological alterations

Protein expression screens are routinely used to identify biological processes deregulated upon disease development or upon specific cellular perturbations. Generating molecular hypotheses from these ‘omic data remains challenging, however, and many molecular events that modulate protein function do not involve altered protein levels. With this project, I propose a new paradigm. I propose that by measuring altered structures of proteins on a global scale, we can capture altered functional states of proteins and proteomes. I propose that the new approach will support the generation of testable molecular hypotheses from global data and the development of new frameworks for the modelling of…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.