ERC Consolidator Grant · 2019
Long noncoding RNAs: Impact on Gene Regulatory Networks
Tens of thousands of loci in mammalian genomes produce long RNAs that do not go on to produce functional proteins, and are collectively called long noncoding RNAs (lncRNAs). A growing number of these have been shown to be important in various biological processes and human diseases. How lncRNA genes function and, specifically, how their production, maturation, or RNA products affect other gene regulatory processes remains poorly understood and is the focus of this proposal. We will build on a rich arsenal of tools from molecular biology, computational biology, high-throughput screens, cell biology, and mouse genetics, develop new methodologies, and dissect the rules underlying the functions…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.