ERC Consolidator Grant · 2019
Deconstructing gene regulation through functional dissection of the 3D genome
The three-dimensional organization of the genome inside the nucleus (3DG) is crucial for gene regulation. Although the fundamental building blocks of the 3DG have been identified, how they contribute to gene regulation is incompletely understood. In recent years my lab has started to functionally dissect the 3DG in order to understand the effects on gene expression. The current proposal intends to expand this work and aims to i) broaden the array of proteins that are known organize the 3DG, ii) determine how loss of these proteins affects the 3DG and iii) elucidate how this influences gene expression. The key to this is to induce changes in the 3DG by acute protein depletion and measuring…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.