Greenberg Lab

Research focus

ERC Starting Grant · 2019

Early embryonic events, life-long consequences: DNA methylation dynamics in mammalian development

Immediately after fertilization, mammalian genomes undergo a dramatic reshaping of the epigenome as the embryo transitions from the zygote into the pluripotent cells primed for lineage commitment. This is best exemplified by DNA methylation reprogramming, as the gametic patterns are largely erased, and the embryonic genome undergoes a wave of de novo DNA methylation. Moreover, once DNA methylation patterns are established, mechanisms faithfully maintain the mark across cell division. Thus, there is latent potential for DNA methylation deposited in the early embryo to exhibit a lifelong effect. DNA methylation is a modification that is typically associated with gene repression at repetitive…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.