ERC Advanced Grant · 2020
The X chromosome is subjected to a formidable degree of concerted gene regulation, with appropriate dosage of X-linked expression in female mammals being ensured by the stable yet reversible inactivation of one of the two copies. The process of X chromosome inactivation (XCI) is critical for female development and linked to sex-specific traits and susceptibilities to various diseases. Well characterized in rodents, there is remarkably little knowledge of how XCI is articulated and controlled in humans, despite its major implication for human health. Here we propose to model in vitro the whole XCI cycle in humans to gain novel and high resolution insights into the key steps of the process…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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