ERC Advanced Grant · 2020
Tissue-wide identification of genome alterations in cancer
We aim to develop the first generation of spatially resolved DNA methodologies to uncover the underlaying molecular landscape of cancer genomes in tissues. Our efforts will focus on a novel genome-wide technology to study genomic integrity in its spatial context, currently a major challenge in the field. The research program is based on developing new experimental protocols and new computational analysis methods. We aim to demonstrate the utility of the method in cancer applications focusing on prostate and breast cancer that display genomic alterations with hallmarks of multiclonality, amplifications and gene fusions. We have previously demonstrated the Spatial Transcriptomics (ST)…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.