ERC Advanced Grant · 2020
DNA binding specificity in-vivo
How transcription factors (TFs) bind rapidly at specific sites within large genomes remains a major mystery. Specificity is puzzling since TFs select a small fraction of their potential binding sites - short and highly abundant DNA motifs. Rapid detection of these selected sites is challenging due to the small motif size and the large number of non-specific sites within a genome. Despite extensive efforts, a unifying model accounting for these challenges, underlying the foundations of gene regulation, is still missing. Our recent results revealed an unexpected role of long intrinsically disordered regions (IDRs) in determining the in-vivo binding specificity of TFs. Long IDRs are ubiquitous…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.