Kind Lab

Research focus

ERC Consolidator Grant · 2020

Learning from the past: linking ancestral epigenetic states to current cellular fates with single-cell multi-omic approaches

The establishment of cell type-specific transcriptional programs involves many interconnected regulatory mechanisms acting on different genomic scales. To dissect this multi-layered control of gene expression in detail, I will develop methods that a) measure multiple cellular outputs in single cells, and b) obtain that information in a time-resolved manner. This proposal outlines my approach to study early mouse development at numerous levels, including (but not limited to) transcription, chromatin context, and nuclear organization. In doing so, I expect to shed light on the mechanism behind cell fate specification and the epigenetic states that precede it. I will develop a novel strategy…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.