Hildebrand Lab

Quadram Institute Bioscience

- · United Kingdom

ERC-funded
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ERC Starting Grant · 2020

Evolution of pro- and eukaryotic commensals within the human gut

The EPYC project will characterize the evolution of long-term human associated eukaryotes and prokaryotes, using colonization patterns in 3 human generations. The gut microbiome is important for human health, supporting nutrition, pathogen defence and immune homeostasis, with more than 200 species inhabiting each human gut. In recent years metagenomics led to notable breakthroughs in describing this microbial diversity, yet 50-90% of species are typically present at too low abundance to be genome or strain resolved. Thus, most gut microbiome studies focused to date on dominant bacteria and very little is known of the highly diverse, yet low abundance, pro- and eukaryotes (elusive microbes).…

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