ERC Advanced Grant · 2021
Decoding animal genomes into cell types
The genome of an animal encodes a large set of regulatory programs that give rise to the thousands of cell types that make up its tissues and organs. Despite recent progress in single-cell omics, our knowledge about the regulatory programs that control the establishment and maintenance of cell type identity remains limited, and methods are lacking to infer regulatory programs directly from the genome sequence. In this project, which lies at the interface between the genome and single-cell atlases, we ask how the genome sequence “translates” into cell types. We start with Drosophila as model organism. Its compactness allows sampling of all its cell types and developmental trajectories from…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.