ERC Consolidator Grant · 2021
Mechanisms and consequences of cell state transitions during heart regeneration
Organs consist of cells with a large diversity of specialized roles. A fundamental question is how these cells mount a coordinated response in space and time to maintain or restore organ function after perturbation. Recent progress in single-cell genomics has generated the opportunity to understand this process on a system-wide scale. We will use the adult zebrafish heart as a powerful model system to dissect how regeneration after injury is orchestrated by the activation response of multiple different cell types. To understand how activated cell states are generated and how they interact to drive the regenerative process, we will: 1) Define which cell types react to injury and measure…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.