ERC Starting Grant · 2021
Bacteria have evolved multiple lines of defense against their viruses, bacteriophages. Such weapons include restriction modification and CRISPR systems that have greatly impacted biomedical research. Studies aimed at uncovering novel defense mechanisms describe an unsuspected diversity of anti-phage systems, spanning thousands of protein families. Several of these anti-phage systems, such as prokaryotic viperins, appear to be ancestors of major eukaryotic antiviral pathways. This striking conservation between eukaryotic and prokaryotic immunity leads me to two hypotheses on which the present proposal is based. First, I postulate that the organisation of antiviral immunity in eukaryotes as…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.