Grosswendt Lab

Charite - University Hospital Berlin

Berlin (DE3) · Germany

ERC-funded
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ERC Starting Grant · 2021

Uncovering the Diversity of Cell-Cell Interactions that Impact Cell Fates

Multicellular life relies on coordinated physical interactions and communication between cells. In these interactions, cells exchange information that determines their fate, physiological state and behavior. The substantial transcriptional heterogeneity that is evident even among cells considered the same type, however, raises questions about exactly which temporal and spatial interactions regulate development and homeostasis. During development, for instance, multipotent neural crest cells migrate along different pathways in which they encounter microenvironments that are thought to instruct their migration and fate choices. To ultimately reveal how cell communication shapes cell…

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